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ABOUT VICTOZA

Buy Victoza Online. Liraglutide, bargained for under the brand name Victoza is an anti-diabetic medication used to treat type 2 diabetesobesity, and chronic weight management. In diabetes, it is a less preferred agent compared to metformin. Its effects on long-term health outcomes like heart disease and life expectancy are unclear. It is given by injection under the skin.

Typical side effects include low blood sugarnauseadizzinessabdominal pain, and pain at the injection site. More series of side effects may include medullary thyroid cancerangioedemapancreatitisgallbladder disease, and kidney problems. Use in pregnancy and breastfeeding is of unclear safety. Liraglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist), also known as incretinmimetics. It works by increasing insulin release from the pancreas and decreasing excessive glucagon release.

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Medical uses

Liraglutide is a medication used to treat type 2 diabetes or obesity.

Type 2 diabetes. 

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Liraglutide improves control of blood glucose. As of 2022, it is unclear if incretin mimetics like liraglutide affect a person’s risk of death.

In diabetes, it is a less preferred agent. It may be used in those in whom metformin and antidiabetic medication such as sulfonylurea are insufficient.

Obesity

Liraglutide may also be used with diet and exercise for chronic weight management in adult patients. The body mass index (BMI) needs to be greater than 30 kg/m2, or greater than 27 kg/m2, with high blood pressure, type 2 diabetes mellitus, or dyslipidemia.

It is unknown if the weight loss will be permanent. Appetite suppression may be temporary, and appetite might return even if one uses liraglutide after 56 weeks.

How does Victoza (Liraglutide) work?

Liraglutide is provided through a daily subcutaneous injection and makes patients feel more full and satisfied with less food. It also reduces the speed by which the stomach empties, making patients being treated with Liraglutide crave less food.

Is Liraglutide effective?

In a Europe-wide trial of 554 people with a body mass index of between 30 and 40 (making them clinically obese), patients lost significant amounts of weight.

Sticking to a calorie-controlled diet and taking exercise, at week 20, the following results were observed:

  • Moderate poundage loss was 7.2kg for those on the 3mg dose, resembled those taking the obesity medication orlistat (Xenical), who lost 4.1 kg, and those taking the placebo, where the average weight loss was only 2.8 kg
  • 76% of patients lost at least 5% of their body weight, compared with 44% on orlistat and 30% on the placebo
  • Patients taking the lower 1.2 mg dose lost 4.8 kg, those taking the 1.8mg dose lost 5.5 kg, and those taking the 2.4mg dose lost 6.3 kg

Can I Buy Victoza (Liraglutide)?

If you are a Type 2 diabetic, you will need to speak to your doctor about this medication to control your condition. You should not attempt to change your treatment regimen without talking to your GP. This is possible if you are scrutinizing to be prescribed Victoza for weight loss. Naming Victoza “off label” for weight loss is being done by some doctors. It is believed that the overall health benefits overshadow the risk of side effects.

What are the side effects of Liraglutide?

Most patients taking Liraglutide did not experience any side effects. Some patients reported nausea and vomiting, but the events were not sufficiently grave to make them stop taking the medication and were generally short-lived.

However, there have been concerns that Liraglutide may cause thyroid tumors after mice develop cancer. However, it is thought that mice have a specific sensitivity, which does not apply to humans. There have also been reports of an increased likelihood of pancreatitis.

When will Liraglutide be available?

Liraglutide has already been approved by the European Medicines Agency for diabetes, so approval as an obesity treatment should be easier than if it were a brand new drug. Clinical trials are ongoing, but preliminary results are highly positive.

Adverse effects

Thyroid cancer

At exposures eight times greater than those used in humans, liraglutide caused a statistically significant increase in thyroid tumors in rats. The clinical relevance of these findings is unknown. In clinical trials, the rate of thyroid tumors in patients treated with liraglutide was 1.3 per 1000 patient-years (4 people) compared to 1.0 per 1000 patients (1 person). The sole person in the comparator group and four persons in the liraglutide group had serum markers suggestive of pre-existing disease at baseline.

The FDA said serum calcitonin, a biomarker of medullary thyroid cancer, was slightly increased in liraglutide patients but still within normal ranges. It required ongoing monitoring for 15 years in a cancer registry.

Pancreatitis

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In 2013, a group at Johns Hopkins reported a statistically significant association between hospitalization for acute pancreatitis and prior treatment with GLP-1 derivatives (such as exenatide) and DPP-4 inhibitors (such as sitagliptin). To reply, the United States FDA and the European Medicines Agency conducted a review of all available data regarding the possible connection between incretin mimetics and pancreatitis or pancreatic cancer. 

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This medicine can cause side effects like all medicines, although not everybody gets them.

Serious side effects

Common: may affect up to 1 in 10 people

  • Symptoms of a drop in blood sugar may appear suddenly and include cold sweat, cold and pale skin, headache, nervousness, anxiety, confusion, difficulty concentrating, and tremors. If you notice these warning symptoms, your doctor will tell you how to treat low blood sugar and what to do. It is more likely to happen if you also use sulfonylurea or insulin. Your doctor may reduce your dose of these medications before you start using Victoza.

Rare: may affect up to 1 in 1,000 people

  • A severe allergic reaction with additional symptoms such as breathing problems, swelling of the throat and face, palpitations, etc. If you notice any of these symptoms, seek medical help immediately and see your doctor as soon as possible.
  • Intestinal obstruction. A severe form of constipation with additional symptoms such as stomach pain, bloating, vomiting, etc.

Very rare: may affect up to 1 in 10,000 people

  • Cases of inflammation of the pancreas (pancreatitis). Pancreatitis can be a severe and life-threatening illness. Stop using Victoza and contact your doctor immediately if you notice any of the following serious side effects:

Severe and persistent pain in the abdomen (stomach area) that can reach the back, and nausea and vomiting could be a sign of inflammation of the pancreas (pancreatitis).

Other adverse effects of Victoza (Liraglutide)

Very common: may affect more than 1 in 10 people

  • This effect typically disappears over time.
  • This effect naturally fades over time.

When Victoza treatment is started, fluid loss/dehydration may be experienced in some cases. For example, in the case of vomiting, nausea, and diarrhea. It is essential to avoid dehydration by drinking plenty of fluids.

  • Headache
  • indigestion
  • Inflamed tummy (gastritis). Signs comprise abdomen discomfort, nauseousness, and vomiting.
  • Gastroesophageal reflux illness (GERD). Manifestation includes heartburn.
  • Bloated stomach (gut) or abdominal discomfort
  • Abdominal distress
  • constipation
  • Gases (flatulence)
  • Diminished craving
  • Bronchitis
  • Common cold
  • dizziness
  • Accelerated palpitation
  • Weariness
  • Toothache
  • Injection spot reactions (bruising, pain, itching, and inflammation).
  • High pancreatic enzymes (such as lipase and amylase).

Abnormal: may affect up to 1 in 100 individuals

  • Allergic reactions such as itching and hives (a type of skin rash)
  • Dehydration, sometimes with decreased kidney function
  • Discomfort (not feeling well)
  • Stones in the gallbladder
  • Inflamed gallbladder

You shouldn’t use Victoza.

Before consuming Victoza, tell your doctor if you,

  • have medical issues with your pancreas, kidneys, or liver.
  • have problems with your belly or the digestion of food
  • if pregnant, intending to become pregnant, or breastfeed

Can I buy Victoza online?

The law requires patients to consult with a doctor to buy prescription drugs. Fortunately, you can have a doctor’s appointment online through CURTIS DIABETIC PHARMACY to determine if Victoza suits your health needs.

Our licensed doctors will help you find the proper care either on the phone or over a video chat. Assume the doctor determines that Victoza (or different prescription medication) is right for you. In that circumstance, they can electronically send a prescription to the pharmacy of your choice.

How is Victoza it used?

Victoza is a solution for injection obtainable in pre‑filled pens (6 mg/ml). Victoza can be given by the patient once a day by injection under the skin in the abdomen, thigh, or upper arm. It is provided independently of meals and preferably each day.
The starting dose of Victoza is 0.6 mg. After at least one week, the amount is increased to 1.2 mg. The quantity can be further expanded to 1.8 mg one week later to better control blood glucose in some patients.
When Victoza is added to existing treatment containing metformin, a thiazolidinedione, or a sodium-glucose cotransporter 2 inhibitor (SGLT2i), the doses of these medicines do not have to be changed. When Victoza is added to treatment with sulphonylurea or insulin, the doctor should consider lowering the amount of the other medication to reduce the risk of having low blood glucose.
The medicine can only be obtained with a prescription. See the package leaflet or contact your doctor or pharmacist for more information about using Victoza.

What benefits of Victoza have been shown in studies?

In six primary studies, Victoza effectively controlled blood glucose concerning 4,289 adults and children with type 2 diabetes. In these studies, the primary measure of effectiveness was reducing the amount of a substance in the blood called glycosylated hemoglobin (HbA1c) after six months or one year of treatment. HbA1c gives an expression of how well the blood glucose is controlled.

In one ‘monotherapy’ study in adults, Victoza on its own was compared with glimepiride (a sulphonylurea). Victoza used on its own was more effective at controlling blood glucose than glimepiride. This study shows that Victoza at a dose of 1.2 mg reduced HbA1c by 0.8 percentage points. In contrast, Victoza at a dose of 1.8 mg led to reductions of 1.1 percentage points. This compared with a decrease of 0.5 percentage points with glimepiride.

In a double therapy study in adults, Victoza plus metformin or Victoza plus glimepiride were compared with metformin or glimepiride taken with a placebo (a dummy treatment). Combinations containing Victoza were more effective at controlling blood glucose than combinations without the medicine. Dual therapies containing Victoza and metformin or glimepiride led to reductions in HbA1c of around 1 percentage point compared with no reduction without Victoza.

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In two ‘triple therapy’ adult studies, Victoza with metformin and glimepiride or rosiglitazone (a thiazolidinedione) were compared with treatments that included placebo or another anti‑diabetes medicine instead of Victoza. The triple therapies containing Victoza reduced between 1.3 and 1.5 percentage points compared with a reduction equal to or less than 0.5 points without Victoza.

In another triple therapy adult study, Victoza was compared with a single dose of short-acting insulin, insulin aspart, when added to treatment with basal insulin (long-acting insulin) plus metformin. Adding Victoza to therapy with basal insulin plus metformin reduced HbA1c by 0.7 percentage points, compared with 0.4 points when adding Victoza to insulin aspart.
In addition to the above studies, Victoza in adults was effective in reducing adverse effects of cardiovascular (heart and blood vessels).

The study involved 9,340 patients with type 2 diabetes who already had cardiovascular disease (angina, heart attack, or stroke). The primary measure of effectiveness was the occurrence of one of three major cardiovascular events: stroke, heart attack, or death caused by cardiovascular disease. Victoza was compared with placebo, and all patients also received standard care. Patients were followed up on average for 3.8 years. Cardiovascular events occurred in 13% (608 out of 4668) of patients taking Victoza compared with 14.9% (694 out of 4672) of patients taking placebo.

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