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Trastuzumab, sold under the brand name Herceptin, is a monoclonal antibody used to treat breast cancer and stomach cancer. Herceptin is used explicitly for cancer that is HER2 receptor-positive. Trastuzumab may be used by itself or together with other chemotherapy medication. Trastuzumab is given by slow injection into a vein and just under the skin.
Common side effects include fever, infection, cough, headache, trouble sleeping, and rash. Other severe side effects include heart failure, allergic reactions, and lung disease. Use during pregnancy may harm the baby. Trastuzumab works by binding to the HER2 receptor and slowing down cell duplication.
Trastuzumab was approved for medical use in the United States in September 1998 and in the European Union in August 2000. It is on the World Health Organization’s List of Essential Medicines. A biosimilar was approved in the European Union in November 2017 and in the United States in December 2018.
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This medication is given by slow injection into a vein by a health care professional, usually once every week or once every three weeks. May be given the first injection of Herceptin over at least 90 minutes.
The dosage depends on your medical condition, response to treatment, weight, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the drug.
Your doctor may prescribe other medications for you to take before each dose to help prevent serious side effects. Follow your doctor’s directions carefully.
See also the Warning section.
Redness/irritation at the injection site, diarrhea, muscle/joint/back pain, stomach/abdominal pain, headache, trouble sleeping, nausea, vomiting, mouth sores, and loss of appetite may occur. Nausea and vomiting can be severe. Your doctor may prescribe medication to prevent or relieve nausea and vomiting in some cases. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. Tell your doctor or pharmacist promptly if any of these effects last or get worse.
Remember that your doctor has prescribed this medication because they have judged that your benefit is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Speak to your doctor right away if you have any severe side effects, such as heart failure (shortness of breath, swollen ankles/feet, unusual tiredness, unusual/sudden weight gain), bone pain, numbness/tingling, mental/mood changes, fast/irregular heartbeat, easy bruising/bleeding.
Get medical help right away if you have any severe side effects, including chest pain, weakness on one side of the body, slurred speech, vision changes, confusion.
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This medication may lower your ability to fight infections may cause the patient more likely to get a serious (rarely fatal) illness or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever, chills, cough).
Trastuzumab can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Tell your doctor right away if you develop any rash.
A severe allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a severe allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. Contact your doctor or pharmacist if you notice other effects not listed above.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
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Visit also the Warning section.
Before using trastuzumab, tell your doctor or pharmacist if you are allergic to it; or any trastuzumab, trastuzumab deruxtecan, trastuzumab emtansine, or trastuzumab-hyaluronidase products; or if you have any other allergies. This product may have inactive components, generating allergic reactions or different concerns. Speak to your pharmacist for more additional details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/recent infection, heart disease, lung issues, last cancer treatments (including radiation medicine).
Trastuzumab can cause you more likely to get infections or aggravate existing conditions. Evade contact with somebody with diseases that may circulate to others (such as chickenpox, measles, flu). Confer your physician if you have been exposed to an illness or for more details.
Accomplish not to have immunizations/vaccinations without the permission of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).
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To decrease the possibility of getting cut, bruised, or injured, be cautious with sharp things like razors and nail cutters, and avoid sports such as contact sports.
This medication may cause you dizziness. Alcohol or marijuana (cannabis) can make you dizzier. Do not drive, use machinery, or do anything that needs alertness until you safely do it. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be at greater risk for heart problems (such as heart failure) while using this drug.
Tell your doctor if you are pregnant or plan to become pregnant. It would be best if you did not become pregnant while using trastuzumab. Trastuzumab may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for seven months after stopping treatment. If you become pregnant, speak to your doctor straight away regarding the dangers and advantages of this medicine.
It is strange if this drug passes into breast milk. Confer your medic before breastfeeding while utilizing this medication and seven months after stopping treatment.
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Visit also the Caution section.
Medicine relations may alter how your medicines function or raise your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or alter the dosage of any medications without your doctor’s approval.
Trastuzumab is very similar to trastuzumab deruxtecan, trastuzumab emtansine, and trastuzumab-hyaluronidase. Do not use a trastuzumab deruxtecan, trastuzumab emtansine, or trastuzumab-hyaluronidase product while using a trastuzumab product.
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If somebody has overdosed and has extreme signs such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canadian inhabitants can contact a regional poison control epicenter.
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